9:00 AM - 9:10 AM (EDT)

Nathan LeBrasseur, Mayo Clinic Rochester

9:10 AM - 9:20 AM (EDT)

Folkert Kuipers, University Medical Center Groningen

9:20 AM - 9:30 AM (EDT)

Satomi Miwa, Newcastle University

9:30 AM - 9:40 AM (EDT)

Laura Niedernhofer, University of Minnesota

9:40 AM - 9:50 AM (EDT)

Lene Juel Rasmussen, University of Copenhagen

9:50 AM - 10:00 AM (EDT)

Björn Schumacher, University of Cologne

10:00 AM - 10:10 AM (EDT)

Round Table QA

10:10 AM - 10:30 AM (EDT)

Nilüfer Ertekin-Taner, Mayo Clinic Florida
Title: Precision medicine in neurodegenerative diseases: Targeting the aging brain

10:30 AM - 10:45 AM (EDT)

Break

10:45 AM - 11:00 AM (EDT)

Alessio Vagnoni, University of Coimbra (PT) and King's College London (UK)
Title: Reduced mitochondrial trafficking is a hallmark of neuronal ageing

11:00 AM - 11:15 AM (EDT)

Wenhui Qiao, Mayo Clinic Florida
Title: APOE genotype modifies benefits of calorie restriction against aging

11:15 AM - 11:30 AM (EDT)

Xu Hou, Mayo Clinic Florida
Title: Enhancing PINK1-PRKN mitophagy to mitigate aging in a novel mouse model

11:30 AM - 11:50 AM (EDT)

Doug Mashek, University of Minnesota
Title: Lipid droplets and genomic stability - a budding relationship

11:50 AM - 12:10 PM (EDT)

Wolfdieter Springer, Mayo Clinic Florida
Title: Genetic activation of PINK1-PRKN mitophagy modulates aging and disease phenotypes

12:10 PM - 12:25 PM (EDT)

Gung Lee, Mayo Clinic Rochester
Title: Dynamics of lipid metabolism in cellular senescence: SASP regulation and therapeutic opportunities for aging

12:25 PM - 12:40 PM (EDT)

Andres Benitez-Rosendo, Mayo Clinic Florida
Title: NAD deficiency in vivo produces changes in metabolism in metabolism that mimics aging in a partially reversible manner

1:40 PM - 2:00 PM (EDT)

Jessica Lancaster, Mayo Clinic Arizona
Title: Disruption of germinal center dynamics by the aged lymph node microenvironment

2:00 PM - 2:15 PM (EDT)

Christina Camell, University of Minnesota
Title: GDF3 promotes adipose tissue macrophage-mediated inflammation via altered chromatin accessibility during aging

2:15 PM - 2:30 PM (EDT)

Tegan McTaggart, Newcastle University
Title: Deciphering novel communication patterns in T regulatory cells from very old adults

2:30 PM - 2:45 PM (EDT)

Stephan Steinke, Mayo Clinic Florida
Title: Cervical lymph node biomarkers: a novel lens into aging and Alzheimer’s disease

3:00 PM - 3:20 PM (EDT)

C. Burcin Taner, Mayo Clinic Florida
Title: Evolution of organ transplantation and challenges in aging population

3:20 PM - 3:40 PM (EDT)

Vincent de Meijer, University Medical Center Groningen
Title: Isolated human liver perfusion as a platform for interventions and repair

3:40 PM - 3:55 PM (EDT)

Adam Thorne, University Medical Center Groningen
Title: Transcriptomic characterization of livers from deceased human donors

3:55 PM - 4:10 PM (EDT)

Ieng Lam Lei, Mayo Clinic Rochester
Title: Brd4-mediated 3D chromatin architecture determines old donor heart preservation quality

4:10 PM - 4:13 PM (EDT)

Neil A. Robertson, Mayo Clinic Rochester
Title: Mutation timing and clonal structure complement fitness in determining clinical progression of clonal hematopoiesis

4:14 PM - 4:16 PM (EDT)

Ines Sturmlechner, Mayo Clinic Rochester
Title: Vaccination-induced Th17 T cells offset the age-related decline in durable T cell immunity

4:17 PM - 4:19 PM (EDT)

Hawley Kunz, Mayo Clinic Rochester
Title: The effects of aging and resistance training on adipose tissue inflammation

4:20 PM - 4:22 PM (EDT)

Chase Carver, Mayo Clinic Rochester
Title: Spatial mapping reveals dominant age-altered populations in mouse brain

4:23 PM - 4:25 PM (EDT)

Helene Martini, Mayo Clinic Rochester
Title: Mitochondrial metabolism and epigenetic crosstalk in senescent cells

4:26 PM - 4:28 PM (EDT)

Yuan Li, University of Copenhagen
Title: Strengthening BNIP3L-related mitophagy pathway as a new strategy to counteract Alzheimer's disease

4:29 PM - 4:31 PM (EDT)

Zhiquan Li, University of Copenhagen
Title: Urolithin A extends healthspan in Drosophila

4:32 PM - 4:34 PM (EDT)

Trevor Kauer, Mayo Clinic Florida
Title: Connecting older adults to clinical trials: developing the ALEX clinical trial referral portal

9:45 AM - 10:05 AM (EDT)

Sundeep Khosla, Mayo Clinic
Title: Biomarkers of senescent cell burden: Implications for clinical trials

10:05 AM - 10:20 AM (EDT)

Beshay Zordoky, University of Minnesota
Title: Immunosenescence and Delayed Cardiovascular Complications of Anthracyclines

10:20 AM - 10:30 AM (EDT)

Break

10:30 AM - 10:45 AM (EDT)

Ana Catarina Franco, Mayo Clinic Rochester
Title: Senescent cell transplantation into the skin induces age-related peripheral dysfunction and cognitive decline

10:45 AM - 11:00 AM (EDT)

Maria Camacho Encina, Newcastle University
Title: Investigating the heterogeneity of senescent cells in human myocardial tissue and its link with cardiovascular disease

11:00 AM - 11:15 AM (EDT)

Teodora Gheorghe, University of Copenhagen
Title: Repurposing calcium channel blockers as novel senolytics

11:15 AM - 11:35 AM (EDT)

Morten Scheibye-Knudsen, University of Copenhagen
Title: Computational approaches to target aging

11:35 AM - 11:55 AM (EDT)

Björn Schumacher, CECAD, University of Cologne
Title: A DREAM master regulator of genome stability and aging clocks in discovery

11:55 AM - 12:10 PM (EDT)

Daniel Simpson, Mayo Clinic Rochester
Title: Characterizing age-related epigenetic changes from a probabilistic inference model

12:10 PM - 12:25 PM (EDT)

David Meyer, University of Cologne
Title: Neuron-type specific aging-rate reveals age decelerating interventions preventing neurodegeneration

12:25 PM - 12:35 PM (EDT)

Closing remarks and awards