http://healthyaging.ku.dk
https://icmm.ku.dk/english/research-groups/juel-rasmussen-group/

Lene Juel Rasmussen is Professor at the University of Copenhagen and Executive Director of the interdisciplinary aging center, Center for Healthy Aging, residing within the Faculty of Health and Medical Sciences. Her research aims to unravel the complex molecular basics of aging and the development of aging associated diseases. Within this context, her research group focuses on the molecular understanding of mitochondrial dysfunction and how cells achieve to preserve mitochondrial and nuclear DNA integrity as well as DNA repair.

The hallmarks of aging, includes genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. A significant amount of scientific evidence has been generated on the role of individual hallmarks on aging, and how they are involved in loss of function and the etiology of age-related diseases. My research addresses whether a specific hallmark by itself could be the primary driver of all aging phenotypes or if different combinations of interactions produce different aging phenotypes. Taken together, emerging evidence points to complex interactions as being the likely driver of aging. I am specifically investigating the interaction between mitochondrial dysfunction and genomic instability.